Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use

VIP Dosage & Reconstitution

Vasoactive Intestinal Peptide, Aviptadil. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: clinical.

1Set Up Your Mix

3.333 mg/mL · 3333 mcg/mL

Your Answer — VIP

10 mg in 3 mL
3Draw To This Line
0.03That's This Many mL
100Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 3
10 mg ÷ 3 mL = 3.333 mg/mL  →  100 mcg ÷ 3.333 mg/mL = 0.03 mL  →  × 100 = 3 units
Looks good. Draw to 3 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 100 doses.
When to dose
Time of dayNo particular time of day has been established.
FoodNo fasting requirement has been established.

The studies behind this compound did not test timing or food state as variables, so we are not going to invent a rule. Pick a time you can keep to consistently.

2Week-By-Week Plan — VIP

Step up from 100 mcg over 8 weeks
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Week 1
start here — 5 days on, 2 days off
100 mcg 5× weekly 0.03 mL 3 u 5 0.5 mg
Weeks 2–3
5 days on, 2 days off
150 mcg 5× weekly 0.045 mL 4.5 u 10 1.5 mg
Weeks 4–8 most stop here
5 days on, 2 days off
200 mcg 5× weekly 0.06 mL 6 u 25 5 mg
Time to get there
8 weeks
Peptide used reaching that
2 mg
Vials you'll need
1 × 10 mg
Ongoing, once you settle
5 mg / 4 wk · 0.5 vials
Where this plan came from
A published protocol
Where this came from: OptimalDosages protocol. Once daily on a five-days-on, two-days-off pattern throughout.

3Common Doses — VIP

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Week 1 100 mcg 5× weekly (5 on, 2 off) 0.03 mL 3 u 100 doses
Weeks 2–3 150 mcg 5× weekly (5 on, 2 off) 0.045 mL 4.5 u 66 doses
Weeks 4–8 200 mcg 5× weekly (5 on, 2 off) 0.06 mL 6 u 50 doses
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About VIP

Immune & Anti-microbial
Also known as
Vasoactive Intestinal Peptide, Aviptadil
Class
Immune & Anti-microbial
Route
Subcutaneous
Half-life
~1–2 min
Evidence tier
Clinical

A 28-amino-acid neuropeptide with vasodilatory and immunomodulatory activity. The aviptadil formulation reached large registered trials in respiratory failure. Use in chronic inflammatory response syndrome is far less well evidenced. Hypotension is a real risk.

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Common Questions — VIP

How much bacteriostatic water do I add to a 10 mg vial of VIP?

Adding 3 mL of bacteriostatic water to a 10 mg vial gives 3.33 mg/mL. That is the mix every number on this page is worked out from — change the water figure in the calculator and all the draw amounts update.

What dose of VIP is used in research?

Published and reported figures for VIP on this protocol run from 100 mcg to 200 mcg, five days a week, stepping up over eight weeks. This site lists each figure with the source it came from rather than giving a single recommended number.

How many units on the syringe is a 100 mcg dose of VIP?

At 3.33 mg/mL, a 100 mcg dose is 3 units on a 1 mL U-100 insulin syringe. One vial at that mix gives about 100 doses.

How strong is the evidence behind these VIP doses?

VIP is graded clinical. Human trial or approved-label dosing has been published for this compound. We grade every compound on this site so you can weigh the numbers accordingly — the full method is on our editorial policy page.

Where These Numbers Come From

Clinical — Human trial or approved-label dosing published
Vasoactive intestinal peptide — an immunomodulatory neuropeptide Delgado M, Ganea D. Amino Acids, 2013
Comprehensive immunology review.
Find on PubMed ↗
Aviptadil in critical COVID-19 respiratory failure — randomised trial Youssef JG, et al. Critical Care Explorations / trial reports, 2022
The registered IV human dosing data.
Find on PubMed ↗

Newest Studies —

Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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