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Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use

VIP Dosage & Reconstitution

Vasoactive Intestinal Peptide, Aviptadil. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: clinical.

1Set Up Your Mix

1 mg/mL · 1000 mcg/mL
All answers assume a standard 1 mL U-100 syringe, where 1 unit = 0.01 mL. That is the usual insulin syringe and the one every number here is based on.

Your Answer — VIPYour Answer

10Draw To This Line
0.1That's This Many mL
100Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 10
10 mg ÷ 10 mL = 1 mg/mL  →  100 mcg ÷ 1 mg/mL = 0.1 mL  →  × 100 = 10 units
Looks good. Draw to 10 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 100 doses.

2Week-By-Week Plan — VIP

Start low, work up
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Low reported 50 mcg up to 4× daily 0.05 mL 5 u 200 doses
Upper reported 100 mcg up to 4× daily 0.1 mL 10 u 100 doses
Trial doseup to 150 pmol/kg/h weight-based12 h ×3 days Set by body weight — can't be turned into a single amount to draw
Weeks until the top dose
2 weeks
Peptide used getting there
0.7 mg
Vials you'll need
1 × 10 mg
Once you're at the top dose
2.8 mg / 4 wk · 0.28 vials
Where this plan came from
Built from this peptide's dose range
Where this came from: Built from the doses listed for this peptide below — start at the lowest and step up, using the studies cited on this page. Nobody publishes a week-by-week plan for this peptide, so we built one: the doses are the researched ones shown below, and we simply put them in order from lowest to highest. Treat it as a starting point, not an official schedule.

3Common Doses — VIP

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Weeks 1–2 50 mcg daily 0.05 mL 5 u 14 0.7 mg
Week 3 onward
per 4 weeks from here on
100 mcg daily 0.1 mL 10 u 28 2.8 mg
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About VIPAbout This Peptide

Immune & Anti-microbial
Also known as
Vasoactive Intestinal Peptide, Aviptadil
Class
Immune & Anti-microbial
Route
Subcutaneous
Half-life
~1–2 min
Evidence tier
Clinical

A 28-amino-acid neuropeptide with vasodilatory and immunomodulatory activity. The aviptadil formulation reached large registered trials in respiratory failure. Use in chronic inflammatory response syndrome is far less well evidenced. Hypotension is a real risk.

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Where These Numbers Come From

Clinical — Human trial or approved-label dosing published
Vasoactive intestinal peptide — an immunomodulatory neuropeptide Delgado M, Ganea D. Amino Acids, 2013
Comprehensive immunology review.
Find on PubMed ↗
Aviptadil in critical COVID-19 respiratory failure — randomised trial Youssef JG, et al. Critical Care Explorations / trial reports, 2022
The registered IV human dosing data.
Find on PubMed ↗

Newest Studies —

Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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