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Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use

PNC-27 Dosage & Reconstitution

p53-derived HDM-2 binding peptide. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: preclinical.

1Set Up Your Mix

20 mg/mL · 20000 mcg/mL
All answers assume a standard 1 mL U-100 syringe, where 1 unit = 0.01 mL. That is the usual insulin syringe and the one every number here is based on.

Your Answer — PNC-27Your Answer

50Draw To This Line
0.5That's This Many mL
1Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 50
10 mg ÷ 0.5 mL = 20 mg/mL  →  10 mg ÷ 20 mg/mL = 0.5 mL  →  × 100 = 50 units
Looks good. Draw to 50 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 1 doses.

2Week-By-Week Plan — PNC-27

not applicable
No week-by-week plan for PNC-27. This one is dosed by body weight, comes ready-mixed, or only has a single dose reported — so there is nothing to work up through.

3Common Doses — PNC-27

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About PNC-27About This Peptide

Immune & Anti-microbial
Also known as
p53-derived HDM-2 binding peptide
Class
Immune & Anti-microbial
Route
Subcutaneous
Half-life
Short
Evidence tier
Preclinical

A p53-derived peptide fused to a membrane-penetrating sequence, reported to selectively lyse cancer cell membranes in vitro and in preclinical tumour models. There are no human trials. Marketing of this compound as a cancer treatment substantially outruns its evidence.

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Where These Numbers Come From

Preclinical — Preclinical and in-vitro data only — no human dosing trials
PNC-27 induces cancer cell necrosis via HDM-2 membrane interaction Michl J, Sarafraz-Yazdi E, Pincus MR, et al. Journal of Molecular Medicine / PLOS ONE, 2006–2019
The originating and follow-up in vitro and preclinical work.
Find on PubMed ↗

Newest Studies —

Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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