p53-derived HDM-2 binding peptide. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: preclinical.
The studies behind this compound did not test timing or food state as variables, so we are not going to invent a rule. Pick a time you can keep to consistently.
| When | Dose | How Often | How Many mL | Draw To | Number Of Doses | Peptide Used |
|---|---|---|---|---|---|---|
| Weeks 1-4 start here |
100 mcg | daily | 0.03 mL | 3 u | 28 | 2.8 mg |
| Weeks 5-8 | 250 mcg | daily | 0.075 mL | 7.5 u | 28 | 7 mg |
| Weeks 9 onward most stop here per 4 weeks from here on |
500 mcg | daily | 0.15 mL | 15 u | 28 | 14 mg |
| Level | Dose | How Often | How Many mL | Draw To | Doses In Vial |
|---|---|---|---|---|---|
| Low (start) | 100 mcg | once daily | 0.03 mL | 3 u | 100 doses |
| Commonly reported | 250 mcg | once daily | 0.075 mL | 7.5 u | 40 doses |
| Upper reported | 500 mcg | once daily | 0.15 mL | 15 u | 20 doses |
A peptide combining a p53 fragment with a penetratin sequence, studied in cancer cell models for selective membrane disruption. Dosed daily in micrograms, not milligrams. No authoritative human dosing exists and the FDA has warned that its safety has not been established.
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Adding 3 mL of bacteriostatic water to a 10 mg vial gives 3.33 mg/mL. That is the mix every number on this page is worked out from — change the water figure in the calculator and all the draw amounts update.
Published and reported figures for PNC-27 run from 10 mg, typically variable. This site lists each figure with the source it came from rather than giving a single recommended number.
At 3.33 mg/mL, a 100 mcg dose is 3 units on a 1 mL U-100 insulin syringe. One vial at that mix gives about 100 doses.
PNC-27 is graded preclinical. Laboratory and animal data only. No human dosing trials have been published. We grade every compound on this site so you can weigh the numbers accordingly — the full method is on our editorial policy page.
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