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Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use

LL-37 Dosage & Reconstitution

Cathelicidin antimicrobial peptide, hCAP-18 fragment. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: preclinical.

1Set Up Your Mix

1 mg/mL · 1000 mcg/mL
All answers assume a standard 1 mL U-100 syringe, where 1 unit = 0.01 mL. That is the usual insulin syringe and the one every number here is based on.

Your Answer — LL-37Your Answer

25Draw To This Line
0.25That's This Many mL
20Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 25
5 mg ÷ 5 mL = 1 mg/mL  →  250 mcg ÷ 1 mg/mL = 0.25 mL  →  × 100 = 25 units
Looks good. Draw to 25 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 20 doses.

2Week-By-Week Plan — LL-37

Start low, work up
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Low reported 100 mcg 1× daily 0.1 mL 10 u 50 doses
Mid reported 250 mcg 1× daily 0.25 mL 25 u 20 doses
Upper 500 mcg 1× daily 0.5 mL 50 u 10 doses
Weeks until the top dose
4 weeks
Peptide used getting there
4.9 mg
Vials you'll need
1 × 5 mg
Once you're at the top dose
14 mg / 4 wk · 2.8 vials
Where this plan came from
Built from this peptide's dose range
Where this came from: Built from the doses listed for this peptide below — start at the lowest and step up, using the studies cited on this page. Nobody publishes a week-by-week plan for this peptide, so we built one: the doses are the researched ones shown below, and we simply put them in order from lowest to highest. Treat it as a starting point, not an official schedule.

3Common Doses — LL-37

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Weeks 1–2 100 mcg daily 0.1 mL 10 u 14 1.4 mg
Weeks 3–4 250 mcg daily 0.25 mL 25 u 14 3.5 mg
Week 5 onward
per 4 weeks from here on
500 mcg daily 0.5 mL 50 u 28 14 mg
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About LL-37About This Peptide

Immune & Anti-microbial
Also known as
Cathelicidin antimicrobial peptide, hCAP-18 fragment
Class
Immune & Anti-microbial
Route
Subcutaneous
Half-life
Short
Evidence tier
Preclinical

The sole human cathelicidin-derived antimicrobial peptide. Well characterised in immunology literature for direct antimicrobial and immunomodulatory activity; also implicated in rosacea and psoriasis pathology, which cuts against naive "more is better" reasoning.

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Where These Numbers Come From

Preclinical — Preclinical and in-vitro data only — no human dosing trials
The human antimicrobial peptide LL-37 — structure and function Dürr UHN, Sudheendra US, Ramamoorthy A. Biochimica et Biophysica Acta, 2006
Standard structural and mechanistic reference.
Find on PubMed ↗
Cathelicidin LL-37 in rosacea and inflammatory skin disease Yamasaki K, Gallo RL. Journal of Dermatological Science, 2007
Documents the pathological side of elevated LL-37 — essential context.
Find on PubMed ↗

Newest Studies —

Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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