Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use

Retatrutide Dosage & Reconstitution

LY3437943, triple GIP/GLP-1/glucagon agonist. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: clinical.

1Set Up Your Mix

10 mg/mL · 10000 mcg/mL

Your Answer — Retatrutide

10 mg in 1 mL
10Draw To This Line
0.1That's This Many mL
10Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 10
10 mg ÷ 1 mL = 10 mg/mL  →  1 mg ÷ 10 mg/mL = 0.1 mL  →  × 100 = 10 units
Looks good. Draw to 10 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 10 doses.
When to dose
Time of dayAny time of day. Weekly compounds should be kept to the same day each week.
FoodWith or without food — it makes no meaningful difference.

These are long-acting and reach steady state over weeks, so a single day’s timing has little effect. Consistency matters more than the hour.

2Week-By-Week Plan — Retatrutide

Weekly 1 mg step-up — most settle at 4–6 mg
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Week 1
let your system adjust
1 mg once weekly 0.1 mL 10 u 1 1 mg
Week 2 2 mg once weekly 0.2 mL 20 u 1 2 mg
Weeks 3–6 most stop here
+1 mg each week — most people stop somewhere in this band
3 6 mg once weekly 0.3 0.6 mL 30 60 u 4 18 mg
Weeks 7–12
only if 6 mg was not enough — +1 mg weekly to the 12 mg ceiling
7 12 mg once weekly 0.7 1.2 mL 70 120 u ⚠ 6 57 mg
Maintenance
whatever dose you settled on — 5 mg shown as the typical case
5 mg once weekly 0.5 mL 50 u 4 20 mg
Time to get there
4–6 weeks for most people
Peptide used reaching that
21 mg
Vials you'll need
3 × 10 mg
Ongoing, once you settle
20 mg / 4 wk · 2 vials
Where this plan came from
An OptimalDosages protocol
Where this came from: 1 mg in week 1 to let the system adjust, 2 mg in week 2, then up by 1 mg each week only for as long as you still need more. Most people find their spot at 4–6 mg and stay there. 12 mg is the ceiling of what was tested in phase 2 — it is not the target, and climbing past 6 mg mostly buys more side effects rather than more effect. Stop increasing the week you get the result you were after. If a week is rough, hold that dose an extra week instead of going up.

3Common Doses — Retatrutide

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Starting dose 1 mg once weekly 0.1 mL 10 u 10 doses
Where most settle 4 mg once weekly 0.4 mL 40 u 2 doses
Where most settle 6 mg once weekly 0.6 mL 60 u 1 doses
Phase 2 arm 8 mg once weekly 0.8 mL 80 u 1 doses
Phase 2 ceiling 12 mg once weekly 1.2 mL 120 u ⚠ — doses
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About Retatrutide

Also known as
LY3437943, triple GIP/GLP-1/glucagon agonist
Class
Metabolic / Incretin
Route
Subcutaneous
Half-life
~6 days
Evidence tier
Clinical

A triple-receptor agonist in ongoing phase 3 development. Phase 2 data reported dose-dependent weight reduction up to 12 mg weekly. In practice most people settle at 4–6 mg once they reach the effect they were after — going higher tends to add side effects rather than results. Not approved anywhere; long-term safety is not established.

Buy Retatrutide

Common Questions — Retatrutide

How much bacteriostatic water do I add to a 10 mg vial of Retatrutide?

Adding 1 mL of bacteriostatic water to a 10 mg vial gives 10 mg/mL. That is the mix every number on this page is worked out from — change the water figure in the calculator and all the draw amounts update.

What dose of Retatrutide is used in research?

Published and reported figures for Retatrutide run from 1 mg to 12 mg, typically once weekly. This site lists each figure with the source it came from rather than giving a single recommended number.

How many units on the syringe is a 1 mg dose of Retatrutide?

At 10 mg/mL, a 1 mg dose is 10 units on a 1 mL U-100 insulin syringe. One vial at that mix gives about 10 doses.

How strong is the evidence behind these Retatrutide doses?

Retatrutide is graded clinical. Human trial or approved-label dosing has been published for this compound. We grade every compound on this site so you can weigh the numbers accordingly — the full method is on our editorial policy page.

Is there a Retatrutide titration schedule?

Yes — Weekly 1 mg step-up — most settle at 4–6 mg. 4–6 weeks for most people The week-by-week table on this page converts each step into the exact amount to draw for your mix.

Where These Numbers Come From

Clinical — Human trial or approved-label dosing published
Triple-hormone-receptor agonist retatrutide for obesity — a phase 2 trial Jastreboff AM, et al. New England Journal of Medicine, 2023
The dose-ranging trial that produced the 1/4/8/12 mg arms cited everywhere.
Find on PubMed ↗
Retatrutide in type 2 diabetes — phase 2 randomised trial Rosenstock J, et al. The Lancet, 2023
Parallel diabetes dose-ranging data.
Find on PubMed ↗

Newest Studies —

Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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