MOTS-c Dosage Calculator & Research Doses

1Set Up Your Mix

40 mg/mL · 40000 mcg/mL

1. Pick your peptide

2. How much peptide is in the vial? It's printed on the label — usually something like 5 mg

3. How much water are you adding? More water makes each dose easier to measure

4. How much do you want per dose?

All answers assume a standard 1 mL U-100 syringe, where 1 unit = 0.01 mL. That is the usual insulin syringe and the one every number here is based on.

Your Answer — MOTS-cYour Answer

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25Draw To This Line

0.25That's This Many mL

4Doses In The Vial

40 mg ÷ 1 mL = 40 mg/mL → 10 mg ÷ 40 mg/mL = 0.25 mL → × 100 = 25 units—

Looks good. Draw to 25 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 4 doses.

2Week-By-Week Plan — MOTS-c

Start low, work up

When	Dose	How Often	How Many mL	Draw To	Number Of Doses
Low reported	5 mg	2–3× weekly	0.125 mL	12.5 u	8 doses
Standard	10 mg	2–3× weekly	0.25 mL	25 u	4 doses
Research study dose	0.5–5 mg/kg weight-based	daily	Set by body weight — can't be turned into a single amount to draw

Weeks until the top dose

2 weeks

Peptide used getting there

25 mg

Vials you'll need

1 × 40 mg

Once you're at the top dose

100 mg / 4 wk · 2.5 vials

Where this plan came from

Built from this peptide's dose range

Where this came from: Built from the doses listed for this peptide below — start at the lowest and step up, using the studies cited on this page. Nobody publishes a week-by-week plan for this peptide, so we built one: the doses are the researched ones shown below, and we simply put them in order from lowest to highest. Treat it as a starting point, not an official schedule.

3Common Doses — MOTS-c

worked out for your mix

Level	Dose	How Often	How Many mL	Draw To	Doses In Vial
Weeks 1–2	5 mg	2.5× weekly	0.125 mL	12.5 u	5	25 mg
Week 3 onward per 4 weeks from here on	10 mg	2.5× weekly	0.25 mL	25 u	10	100 mg

Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About MOTS-cAbout This Peptide

Mitochondrial

Also known as

Mitochondrial ORF of the 12S rRNA type-c

Class

Mitochondrial

Route

Subcutaneous

Half-life

Short

Evidence tier

Preclinical

A mitochondrial-derived peptide acting via AMPK on insulin sensitivity and metabolic homeostasis. Genuinely interesting mechanism with solid research data and human observational correlations, but no human dosing trials.

Buy MOTS-cthis peptide

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Where These Numbers Come From

Preclinical — Preclinical and in-vitro data only — no human dosing trials

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance Lee C, et al. Cell Metabolism, 2015

The discovery paper; source of all research dosing figures.

Find on PubMed ↗

MOTS-c in exercise and skeletal muscle adaptation Reynolds JC, et al. Nature Communications, 2021

Extends the mechanism to exercise capacity and healthspan in preclinical models.

Find on PubMed ↗

Newest Studies — —

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Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

Research Use Only — Confirm to Continue

MOTS-c Dosage & Reconstitution

1Set Up Your Mix

Your Answer — MOTS-cYour Answer

2Week-By-Week Plan — MOTS-c

3Common Doses — MOTS-c

About MOTS-cAbout This Peptide

Where These Numbers Come From

Newest Studies — —

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