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Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use
OptimalDosages

GHK-Cu Dosage & Reconstitution

Copper tripeptide-1, Gly-His-Lys-Cu. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: clinical.

1Set Up Your Mix

8.333 mg/mL · 8333 mcg/mL
All answers assume a standard 1 mL U-100 syringe, where 1 unit = 0.01 mL. That is the usual insulin syringe and the one every number here is based on.

Your Answer — GHK-CuYour Answer

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24Draw To This Line
0.24That's This Many mL
25Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 24
50 mg ÷ 6 mL = 8.333 mg/mL  →  2 mg ÷ 8.333 mg/mL = 0.24 mL  →  × 100 = 24 units—
Looks good. Draw to 24 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 25 doses.

2Week-By-Week Plan — GHK-Cu

Start low, work up
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Reported concentration0.5–2% concentration1–2× daily Set by body weight — can't be turned into a single amount to draw
Low reported (SC) 1 mg 1× daily 0.12 mL 12 u 50 doses
Standard (SC) 2 mg 1× daily 0.24 mL 24 u 25 doses
Upper reported 3 mg 1× daily 0.36 mL 36 u 16 doses
Weeks until the top dose
4 weeks
Peptide used getting there
42 mg
Vials you'll need
1 × 50 mg
Once you're at the top dose
84 mg / 4 wk · 1.68 vials
Where this plan came from
Built from this peptide's dose range
Where this came from: Built from the doses listed for this peptide below — start at the lowest and step up, using the studies cited on this page. Nobody publishes a week-by-week plan for this peptide, so we built one: the doses are the researched ones shown below, and we simply put them in order from lowest to highest. Treat it as a starting point, not an official schedule.

3Common Doses — GHK-Cu

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Weeks 1–2 1 mg daily 0.12 mL 12 u 14 14 mg
Weeks 3–4 2 mg daily 0.24 mL 24 u 14 28 mg
Week 5 onward
per 4 weeks from here on		 3 mg daily 0.36 mL 36 u 28 84 mg
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About GHK-CuAbout This Peptide

Cosmetic & Dermal
Also known as
Copper tripeptide-1, Gly-His-Lys-Cu
Class
Cosmetic & Dermal
Route
Subcutaneous
Half-life
Short systemically
Evidence tier
Clinical

A copper-binding tripeptide present in human plasma, declining with age. The strongest evidence covers collagen synthesis, wound healing and skin remodelling. Copper-containing solutions are photosensitive and should not be mixed with certain diluents; check compatibility.

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Where These Numbers Come From

Clinical — Human trial or approved-label dosing published
Regenerative and protective actions of the GHK-Cu peptide Pickart L, Margolina A. International Journal of Molecular Sciences, 2018
Comprehensive review by the researcher who originally isolated GHK; covers gene-expression and wound data.
Find on PubMed ↗
Effect of copper tripeptide on photoaged facial skin Finkey MB, et al. clinical dermatology trials, 2005
Human topical data on wrinkle depth and skin density.
Find on PubMed ↗
GHK peptide as a natural modulator of multiple cellular pathways Pickart L, Vasquez-Soltero JM, Margolina A. BioMed Research International, 2015
Gene-expression profiling underpinning the broader claims.
Find on PubMed ↗

Newest Studies — —

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Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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