Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use

Melanotan II Dosage & Reconstitution

MT-2, cyclic α-MSH analogue. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: preclinical.

1Set Up Your Mix

3.333 mg/mL · 3333 mcg/mL

Your Answer — Melanotan II

10 mg in 3 mL
7.5Draw To This Line
0.075That's This Many mL
40Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 7.5
10 mg ÷ 3 mL = 3.333 mg/mL  →  250 mcg ÷ 3.333 mg/mL = 0.075 mL  →  × 100 = 7.5 units
Looks good. Draw to 7.5 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 40 doses.
When to dose
Time of dayNo particular time of day has been established.
FoodNo fasting requirement has been established.

The studies behind this compound did not test timing or food state as variables, so we are not going to invent a rule. Pick a time you can keep to consistently.

2Week-By-Week Plan — Melanotan II

Loading and maintenance phases
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Loading — weeks 1–2 250 mcg daily 0.075 mL 7.5 u 14 3.5 mg
Loading — weeks 3–4 500 mcg daily 0.15 mL 15 u 14 7 mg
Maintenance — week 5 onward
per 4 weeks from here on
500 mcg twice weekly 0.15 mL 15 u 8 4 mg
Time until the top dose
4 weeks
Peptide used getting there
10.5 mg
Vials you'll need
2 × 10 mg
Once you're at the top dose
4 mg / 4 wk · 0.4 vials
Where this plan came from
A commonly used protocol
Where this came from: Convention within the research community — not derived from a registered trial. Loading then maintenance. Note the safety record in the profile above — this compound has documented case reports of dysplastic naevi and melanoma associated with unregulated use.

3Common Doses — Melanotan II

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Loading (reported) 250 mcg 1× daily 0.075 mL 7.5 u 40 doses
Standard (reported) 500 mcg 1× daily 0.15 mL 15 u 20 doses
Maintenance (reported) 500 mcg 1–2× weekly 0.15 mL 15 u 20 doses
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About Melanotan II

Cosmetic & Dermal
Also known as
MT-2, cyclic α-MSH analogue
Class
Cosmetic & Dermal
Route
Subcutaneous
Half-life
~1–2 h
Evidence tier
Preclinical

A non-selective melanocortin agonist producing pigmentation, appetite suppression and erectile effects. Carries documented safety concerns: nausea, blood pressure changes, and case reports of dysplastic naevi and melanoma associated with unregulated use. Bremelanotide (PT-141) is the selectively developed descendant.

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Common Questions — Melanotan II

How much bacteriostatic water do I add to a 10 mg vial of Melanotan II?

Adding 3 mL of bacteriostatic water to a 10 mg vial gives 3.33 mg/mL. That is the mix every number on this page is worked out from — change the water figure in the calculator and all the draw amounts update.

What dose of Melanotan II is used in research?

Published and reported figures for Melanotan II run from 250 mcg to 500 mcg, typically 1× daily. This site lists each figure with the source it came from rather than giving a single recommended number.

How many units on the syringe is a 250 mcg dose of Melanotan II?

At 3.33 mg/mL, a 250 mcg dose is 7.5 units on a 1 mL U-100 insulin syringe. One vial at that mix gives about 40 doses.

How strong is the evidence behind these Melanotan II doses?

Melanotan II is graded preclinical. Laboratory and animal data only. No human dosing trials have been published. We grade every compound on this site so you can weigh the numbers accordingly — the full method is on our editorial policy page.

Is there a Melanotan II titration schedule?

Yes — Loading and maintenance phases. The week-by-week table on this page converts each step into the exact amount to draw for your mix.

Where These Numbers Come From

Preclinical — Preclinical and in-vitro data only — no human dosing trials
Melanotan II — melanocortin agonist pharmacology in humans Dorr RT, et al. Life Sciences / Journal of Clinical Endocrinology, 1996–2000
The original human pharmacology and pigmentation data.
Find on PubMed ↗
Melanoma and dysplastic naevi associated with unregulated melanotan use Multiple case series, British Journal of Dermatology / JAMA Dermatology, 2009–2019
The safety literature. Read this before the efficacy literature.
Find on PubMed ↗

Newest Studies —

Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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