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Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use

Survodutide Dosage & Reconstitution

BI 456906, GLP-1/glucagon dual agonist. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: clinical.

1Set Up Your Mix

10 mg/mL · 10000 mcg/mL
All answers assume a standard 1 mL U-100 syringe, where 1 unit = 0.01 mL. That is the usual insulin syringe and the one every number here is based on.

Your Answer — SurvodutideYour Answer

24Draw To This Line
0.24That's This Many mL
4Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 24
10 mg ÷ 1 mL = 10 mg/mL  →  2.4 mg ÷ 10 mg/mL = 0.24 mL  →  × 100 = 24 units
Looks good. Draw to 24 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 4 doses.

2Week-By-Week Plan — Survodutide

Phase 2 escalation
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Initiation 0.6 mg once weekly 0.06 mL 6 u 16 doses
Step 2.4 mg once weekly 0.24 mL 24 u 4 doses
Step 3.6 mg once weekly 0.36 mL 36 u 2 doses
Trial max 6 mg once weekly 0.6 mL 60 u 1 doses
Weeks until the top dose
16 weeks
Peptide used getting there
31.2 mg
Vials you'll need
4 × 10 mg
Once you're at the top dose
24 mg / 4 wk · 2.4 vials
Where this plan came from
A clinical trial schedule
Where this came from: Lancet Diabetes & Endocrinology phase 2 programme. The phase 2 programme tested both rapid and gradual escalation arms; the steps below follow a four-week cadence toward the 6.0 mg arm.

3Common Doses — Survodutide

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Weeks 1–4 0.6 mg once weekly 0.06 mL 6 u 4 2.4 mg
Weeks 5–8 1.2 mg once weekly 0.12 mL 12 u 4 4.8 mg
Weeks 9–12 2.4 mg once weekly 0.24 mL 24 u 4 9.6 mg
Weeks 13–16 3.6 mg once weekly 0.36 mL 36 u 4 14.4 mg
Week 17 onward
per 4 weeks from here on
6 mg once weekly 0.6 mL 60 u 4 24 mg
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About SurvodutideAbout This Peptide

Metabolic / Incretin
Also known as
BI 456906, GLP-1/glucagon dual agonist
Class
Metabolic / Incretin
Route
Subcutaneous
Half-life
~6 days
Evidence tier
Clinical

A dual GLP-1/glucagon receptor agonist in phase 3, with notable phase 2 results in MASH as well as obesity.

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Where These Numbers Come From

Clinical — Human trial or approved-label dosing published
Survodutide for the treatment of obesity — phase 2 randomised trial le Roux CW, et al. The Lancet Diabetes & Endocrinology, 2024
Source of the 0.6–6.0 mg escalation arms.
Find on PubMed ↗
Survodutide in metabolic dysfunction-associated steatohepatitis Sanyal AJ, et al. New England Journal of Medicine, 2024
MASH endpoint data at the same dose range.
Find on PubMed ↗

Newest Studies —

Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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