Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use

Semax Dosage & Reconstitution

ACTH(4-7)-Pro-Gly-Pro. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: clinical.

1Set Up Your Mix

5 mg/mL · 5000 mcg/mL

Your Answer — Semax

10 mg in 2 mL
4Draw To This Line
0.04That's This Many mL
50Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 4
10 mg ÷ 2 mL = 5 mg/mL  →  200 mcg ÷ 5 mg/mL = 0.04 mL  →  × 100 = 4 units
Looks good. Draw to 4 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 50 doses.
When to dose
Time of dayMorning or early afternoon.
FoodWith or without food.

Several compounds in this class are stimulating for some people; dosing late can interfere with sleep.

2Week-By-Week Plan — Semax

Start low, work up
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Weeks 1–2 200 mcg daily 0.04 mL 4 u 14 2.8 mg
Weeks 3–4 400 mcg daily 0.08 mL 8 u 14 5.6 mg
Week 5 onward
per 4 weeks from here on
600 mcg daily 0.12 mL 12 u 28 16.8 mg
Time until the top dose
4 weeks
Peptide used getting there
8.4 mg
Vials you'll need
1 × 10 mg
Once you're at the top dose
16.8 mg / 4 wk · 1.68 vials
Where this plan came from
Built from this peptide's dose range
Where this came from: Built from the doses listed for this peptide below — start at the lowest and step up, using the studies cited on this page. Nobody publishes a week-by-week plan for this peptide, so we built one: the doses are the researched ones shown below, and we simply put them in order from lowest to highest. Treat it as a starting point, not an official schedule.

3Common Doses — Semax

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Low reported 200 mcg 1–2× daily 0.04 mL 4 u 50 doses
Standard 400 mcg 1–2× daily 0.08 mL 8 u 25 doses
Upper reported 600 mcg 1–2× daily 0.12 mL 12 u 16 doses
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About Semax

Cognitive & Neuro
Also known as
ACTH(4-7)-Pro-Gly-Pro
Class
Cognitive & Neuro
Route
Subcutaneous
Half-life
Short
Evidence tier
Clinical

A synthetic ACTH fragment analogue registered as a medicine in Russia for stroke and cognitive indications. Substantial Russian clinical literature; almost no Western replication.

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Common Questions — Semax

How much bacteriostatic water do I add to a 10 mg vial of Semax?

Adding 2 mL of bacteriostatic water to a 10 mg vial gives 5 mg/mL. That is the mix every number on this page is worked out from — change the water figure in the calculator and all the draw amounts update.

What dose of Semax is used in research?

Published and reported figures for Semax run from 200 mcg to 600 mcg, typically 1–2× daily. This site lists each figure with the source it came from rather than giving a single recommended number.

How many units on the syringe is a 200 mcg dose of Semax?

At 5 mg/mL, a 200 mcg dose is 4 units on a 1 mL U-100 insulin syringe. One vial at that mix gives about 50 doses.

How strong is the evidence behind these Semax doses?

Semax is graded clinical. Human trial or approved-label dosing has been published for this compound. We grade every compound on this site so you can weigh the numbers accordingly — the full method is on our editorial policy page.

Where These Numbers Come From

Clinical — Human trial or approved-label dosing published
Semax in the treatment of ischaemic stroke — clinical experience Gusev EI, Skvortsova VI, et al. Russian neurology journals, 1997–2010s
The main body of clinical data; Russian-language, limited international review.
Find on PubMed ↗
Semax and BDNF expression in rat hippocampus Dolotov OV, et al. Journal of Neuroscience Research / Neuroscience Letters, 2006
The mechanistic BDNF claim, in preclinical models.
Find on PubMed ↗

Newest Studies —

Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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