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Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use

ARA-290 Dosage & Reconstitution

Cibinetide, EPO helix-B surface peptide. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: clinical.

1Set Up Your Mix

8 mg/mL · 8000 mcg/mL
All answers assume a standard 1 mL U-100 syringe, where 1 unit = 0.01 mL. That is the usual insulin syringe and the one every number here is based on.

Your Answer — ARA-290Your Answer

25Draw To This Line
0.25That's This Many mL
8Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 25
16 mg ÷ 2 mL = 8 mg/mL  →  2 mg ÷ 8 mg/mL = 0.25 mL  →  × 100 = 25 units
Looks good. Draw to 25 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 8 doses.

2Week-By-Week Plan — ARA-290

Start low, work up
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Trial dose 4 mg daily ×28 days 0.5 mL 50 u 4 doses
Trial dose 2 mg daily 0.25 mL 25 u 8 doses
Extended 4 mg daily, longer courses 0.5 mL 50 u 4 doses
Weeks until the top dose
2 weeks
Peptide used getting there
28 mg
Vials you'll need
2 × 16 mg
Once you're at the top dose
112 mg / 4 wk · 7 vials
Where this plan came from
Built from this peptide's dose range
Where this came from: Built from the doses listed for this peptide below — start at the lowest and step up, using the studies cited on this page. Nobody publishes a week-by-week plan for this peptide, so we built one: the doses are the researched ones shown below, and we simply put them in order from lowest to highest. Treat it as a starting point, not an official schedule.

3Common Doses — ARA-290

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Weeks 1–2 2 mg daily 0.25 mL 25 u 14 28 mg
Week 3 onward
per 4 weeks from here on
4 mg daily 0.5 mL 50 u 28 112 mg
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About ARA-290About This Peptide

Cognitive & Neuro
Also known as
Cibinetide, EPO helix-B surface peptide
Class
Cognitive & Neuro
Route
Subcutaneous
Half-life
~2 min (tissue effect far longer)
Evidence tier
Clinical

An 11-amino-acid erythropoietin derivative that engages the innate repair receptor without the erythropoietic or thrombotic effects of EPO. Studied in sarcoidosis-associated small fibre neuropathy and diabetic neuropathy with genuine registered trials.

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Where These Numbers Come From

Clinical — Human trial or approved-label dosing published
ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fibre loss Dahan A, et al. Molecular Medicine, 2013
The primary randomised human trial; source of the 4 mg daily figure.
Find on PubMed ↗
Erythropoietin-derived non-erythropoietic peptides and tissue protection Brines M, Cerami A. Journal of Internal Medicine, 2008
Mechanistic basis — the innate repair receptor concept.
Find on PubMed ↗

Newest Studies —

Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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