PE-22-28 Dosage Calculator & Research Doses

1Set Up Your Mix

2 mg/mL · 2000 mcg/mL

1. Pick your peptide

2. How much peptide is in the vial? It's printed on the label — usually something like 5 mg

3. How much water are you adding? More water makes each dose easier to measure

4. How much do you want per dose?

All answers assume a standard 1 mL U-100 syringe, where 1 unit = 0.01 mL. That is the usual insulin syringe and the one every number here is based on.

Your Answer — PE-22-28Your Answer

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25Draw To This Line

0.25That's This Many mL

20Doses In The Vial

10 mg ÷ 5 mL = 2 mg/mL → 500 mcg ÷ 2 mg/mL = 0.25 mL → × 100 = 25 units—

Looks good. Draw to 25 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 20 doses.

2Week-By-Week Plan — PE-22-28

Start low, work up

When	Dose	How Often	How Many mL	Draw To	Number Of Doses
Research study dose	~0.1 mg/kg weight-based	daily	Set by body weight — can't be turned into a single amount to draw
Community reported	250 mcg	1× daily	0.125 mL	12.5 u	40 doses
Community upper	500 mcg	1× daily	0.25 mL	25 u	20 doses

Weeks until the top dose

2 weeks

Peptide used getting there

3.5 mg

Vials you'll need

1 × 10 mg

Once you're at the top dose

14 mg / 4 wk · 1.4 vials

Where this plan came from

Built from this peptide's dose range

Where this came from: Built from the doses listed for this peptide below — start at the lowest and step up, using the studies cited on this page. Nobody publishes a week-by-week plan for this peptide, so we built one: the doses are the researched ones shown below, and we simply put them in order from lowest to highest. Treat it as a starting point, not an official schedule.

3Common Doses — PE-22-28

worked out for your mix

Level	Dose	How Often	How Many mL	Draw To	Doses In Vial
Weeks 1–2	250 mcg	daily	0.125 mL	12.5 u	14	3.5 mg
Week 3 onward per 4 weeks from here on	500 mcg	daily	0.25 mL	25 u	28	14 mg

Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About PE-22-28About This Peptide

Cognitive & Neuro

Also known as

Spadin analogue, TREK-1 blocker

Class

Cognitive & Neuro

Route

Subcutaneous

Half-life

Short

Evidence tier

Preclinical

A shortened spadin analogue that blocks the TREK-1 potassium channel, proposed as a fast-acting antidepressant mechanism. Preclinical data only.

Buy PE-22-28this peptide

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Where These Numbers Come From

Preclinical — Preclinical and in-vitro data only — no human dosing trials

Spadin and shortened analogues as TREK-1 blockers with antidepressant properties Veyssiere J, Moha ou Maati H, et al. British Journal of Pharmacology, 2015

The originating pharmacology; source of PE-22-28 specifically.

Find on PubMed ↗

Newest Studies — —

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Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

Research Use Only — Confirm to Continue

PE-22-28 Dosage & Reconstitution

1Set Up Your Mix

Your Answer — PE-22-28Your Answer

2Week-By-Week Plan — PE-22-28

3Common Doses — PE-22-28

About PE-22-28About This Peptide

Where These Numbers Come From

Newest Studies — —

More peptides

DSIP

ARA-290

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