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Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use
OptimalDosages

Mazdutide Dosage & Reconstitution

IBI362, LY3305677, GLP-1/glucagon agonist. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: clinical.

1Set Up Your Mix

10 mg/mL · 10000 mcg/mL
All answers assume a standard 1 mL U-100 syringe, where 1 unit = 0.01 mL. That is the usual insulin syringe and the one every number here is based on.

Your Answer — MazdutideYour Answer

—
45Draw To This Line
0.45That's This Many mL
1Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 45
5 mg ÷ 0.5 mL = 10 mg/mL  →  4.5 mg ÷ 10 mg/mL = 0.45 mL  →  × 100 = 45 units—
Looks good. Draw to 45 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 1 doses.

2Week-By-Week Plan — Mazdutide

Start low, work up
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Low arm 3 mg once weekly 0.3 mL 30 u 1 doses
Mid arm 4.5 mg once weekly 0.45 mL 45 u 1 doses
High arm 6 mg once weekly 0.6 mL 60 u — doses
Top arm 9 mg once weekly 0.9 mL 90 u — doses
Weeks until the top dose
12 weeks
Peptide used getting there
54 mg
Vials you'll need
11 × 5 mg
Once you're at the top dose
36 mg / 4 wk · 7.2 vials
Where this plan came from
Built from this peptide's dose range
Where this came from: Built from the doses listed for this peptide below — start at the lowest and step up, using the studies cited on this page. Nobody publishes a week-by-week plan for this peptide, so we built one: the doses are the researched ones shown below, and we simply put them in order from lowest to highest. Treat it as a starting point, not an official schedule.

3Common Doses — Mazdutide

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Weeks 1–4 3 mg once weekly 0.3 mL 30 u 4 12 mg
Weeks 5–8 4.5 mg once weekly 0.45 mL 45 u 4 18 mg
Weeks 9–12 6 mg once weekly 0.6 mL 60 u 4 24 mg
Week 13 onward
per 4 weeks from here on		 9 mg once weekly 0.9 mL 90 u 4 36 mg
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About MazdutideAbout This Peptide

Metabolic / Incretin
Also known as
IBI362, LY3305677, GLP-1/glucagon agonist
Class
Metabolic / Incretin
Route
Subcutaneous
Half-life
~5–6 days
Evidence tier
Clinical

A GLP-1/glucagon dual agonist developed primarily in Chinese phase 2/3 programmes.

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Where These Numbers Come From

Clinical — Human trial or approved-label dosing published
Mazdutide in Chinese adults with overweight or obesity — phase 2 Ji L, et al. The Lancet Diabetes & Endocrinology, 2023/2024
Primary dose-ranging source.
Find on PubMed ↗

Newest Studies — —

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Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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