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Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use

Cagrilintide Dosage & Reconstitution

Long-acting amylin analogue. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: clinical.

1Set Up Your Mix

2.5 mg/mL · 2500 mcg/mL
All answers assume a standard 1 mL U-100 syringe, where 1 unit = 0.01 mL. That is the usual insulin syringe and the one every number here is based on.

Your Answer — CagrilintideYour Answer

24Draw To This Line
0.24That's This Many mL
8Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 24
5 mg ÷ 2 mL = 2.5 mg/mL  →  0.6 mg ÷ 2.5 mg/mL = 0.24 mL  →  × 100 = 24 units
Looks good. Draw to 24 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 8 doses.

2Week-By-Week Plan — Cagrilintide

Phase 2 escalation
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Initiation 0.3 mg once weekly 0.12 mL 12 u 16 doses
Step 0.6 mg once weekly 0.24 mL 24 u 8 doses
Step 1.2 mg once weekly 0.48 mL 48 u 4 doses
Trial max 2.4 mg once weekly 0.96 mL 96 u 2 doses
Weeks until the top dose
12 weeks
Peptide used getting there
8.4 mg
Vials you'll need
2 × 5 mg
Once you're at the top dose
9.6 mg / 4 wk · 1.92 vials
Where this plan came from
A clinical trial schedule
Where this came from: Lancet phase 2 dose-escalation, four-week steps. Four-week steps. The trial also ran a 4.5 mg arm above the range shown here; exact escalation varied by arm.

3Common Doses — Cagrilintide

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Weeks 1–4 0.3 mg once weekly 0.12 mL 12 u 4 1.2 mg
Weeks 5–8 0.6 mg once weekly 0.24 mL 24 u 4 2.4 mg
Weeks 9–12 1.2 mg once weekly 0.48 mL 48 u 4 4.8 mg
Week 13 onward
per 4 weeks from here on
2.4 mg once weekly 0.96 mL 96 u 4 9.6 mg
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About CagrilintideAbout This Peptide

Metabolic / Incretin
Also known as
Long-acting amylin analogue
Class
Metabolic / Incretin
Route
Subcutaneous
Half-life
~7–8 days
Evidence tier
Clinical

An amylin analogue studied alone and in fixed combination with semaglutide (CagriSema). Escalation mirrors the GLP-1 pattern.

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Where These Numbers Come From

Clinical — Human trial or approved-label dosing published
Once-weekly cagrilintide for weight management — a phase 2 trial Lau DCW, et al. The Lancet, 2021
Dose-ranging source for the 0.3–4.5 mg arms.
Find on PubMed ↗
CagriSema — cagrilintide plus semaglutide combination trials Frías JP, et al. The Lancet, 2023
Combination dosing and additive effect data.
Find on PubMed ↗

Newest Studies —

Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

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