Retatrutide 5 mg + Cagrilintide 5 mg. Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: preclinical.
The studies behind this compound did not test timing or food state as variables, so we are not going to invent a rule. Pick a time you can keep to consistently.
| When | Dose | How Often | How Many mL | Draw To | Number Of Doses | Peptide Used |
|---|---|---|---|---|---|---|
| Weeks 1–4 | 1.2 mg | once weekly | 0.12 mL | 12 u | 4 | 4.8 mg |
| Weeks 5–8 | 2.4 mg | once weekly | 0.24 mL | 24 u | 4 | 9.6 mg |
| Week 9 onward per 4 weeks from here on |
4.8 mg | once weekly | 0.48 mL | 48 u | 4 | 19.2 mg |
| Level | Dose | How Often | How Many mL | Draw To | Doses In Vial |
|---|---|---|---|---|---|
| Low reported | 1.2 mg | once weekly · 0.6 mg of each compound | 0.12 mL | 12 u | 8 doses |
| Standard | 2.4 mg | once weekly · 1.2 mg of each compound | 0.24 mL | 24 u | 4 doses |
| Upper reported | 4.8 mg | once weekly · 2.4 mg of each compound | 0.48 mL | 48 u | 2 doses |
Equal parts of a triple incretin agonist and an amylin analogue — 5 mg of each in a 10 mg vial, once weekly. The thing to understand before dosing it: the two components were trialled on very different scales. Retatrutide ran up to 12 mg weekly, cagrilintide only to 2.4 mg. Because a 1:1 blend moves both together, cagrilintide hits its ceiling at 4.8 mg total — and at that point retatrutide is still only at 2.4 mg, nowhere near its higher arms. Cagrilintide is what caps this blend, and pushing past it takes the amylin component beyond anything that has been tested.
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Adding 1 mL of bacteriostatic water to a 10 mg vial gives 10 mg/mL. That is the mix every number on this page is worked out from — change the water figure in the calculator and all the draw amounts update.
Published and reported figures for Retatrutide / Cagrilintide Blend run from 1.2 mg to 4.8 mg, typically once weekly (0.6 mg each).2 mg to 4.8 mg, typically once weekly (0.6 mg each). This site lists each figure with the source it came from rather than giving a single recommended number.
At 10 mg/mL, a 1.2 mg dose is 12 units on a 1 mL U-100 insulin syringe. One vial at that mix gives about 8 doses.
Retatrutide / Cagrilintide Blend is graded preclinical. Laboratory and animal data only. No human dosing trials have been published. We grade every compound on this site so you can weigh the numbers accordingly — the full method is on our editorial policy page.
Two different appetite pathways. Retatrutide is a triple GIP/GLP-1/glucagon agonist; cagrilintide is a long-acting amylin analogue. Amylin and incretin signalling are separate systems, and combining them is an active area of clinical development — the cagrilintide plus semaglutide combination has been trialled in humans.
That said, this specific pairing has not. And retatrutide itself is not approved anywhere, so a blend containing it inherits every caveat on the retatrutide page.
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