FOXO4-DRI Dosage Calculator & Chart

1Set Up Your Mix

5 mg/mL · 5000 mcg/mL

1. Pick your peptide

2. How much peptide is in the vial? It's printed on the label — usually something like 5 mg

3. How much water are you adding? More water makes each dose easier to measure

4. How much do you want per dose?

Your Answer — FOXO4-DRI

10 mg in 2 mL

5Draw To This Line

0.05That's This Many mL

40Doses In The Vial

10 mg ÷ 2 mL = 5 mg/mL → 250 mcg ÷ 5 mg/mL = 0.05 mL → × 100 = 5 units

Looks good. Draw to 5 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 40 doses.

When to dose

Time of dayNo particular time of day has been established.

FoodNo fasting requirement has been established.

The studies behind this compound did not test timing or food state, so we are not going to invent a rule.

2Week-By-Week Plan — FOXO4-DRI

Gradual daily titration

When	Dose	How Often	How Many mL	Draw To	Number Of Doses	Peptide Used
Weeks 1-4 start here	250 mcg	daily	0.05 mL	5 u	28	7 mg
Weeks 5-8	375 mcg	daily	0.075 mL	7.5 u	28	10.5 mg
Weeks 9-16 onward most stop here target dose	500 mcg	daily	0.1 mL	10 u	56	28 mg

Time to get there

9 weeks to the 500 mcg target

Peptide used reaching that

17.5 mg

Vials you'll need

2 × 10 mg

Ongoing, once you settle

28 mg / 4 wk · 2.8 vials

Where this plan came from

A published protocol

Where this came from: The peptidedosages.com 10 mg protocol - 250 mcg daily, rising over 16 weeks. There is no human clinical dosing data for FOXO4-DRI. These figures come from an educational protocol built on preclinical work, not from a trial, and tolerability in people is uncharacterised.

3Common Doses — FOXO4-DRI

worked out for your mix

Level	Dose	How Often	How Many mL	Draw To	Doses In Vial
Weeks 1-4 (start)	250 mcg	once daily	0.05 mL	5 u	40 doses
Weeks 5-8	375 mcg	once daily	0.075 mL	7.5 u	26 doses
Weeks 9-16 (target)	500 mcg	once daily	0.1 mL	10 u	20 doses

Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About FOXO4-DRI

Longevity & Bioregulator

Also known as

FOXO4-D-Retro-Inverso peptide

Class

Longevity & Bioregulator

Route

Subcutaneous

Half-life

Short

Evidence tier

Preclinical

A D-retro-inverso senolytic peptide that disrupts the FOXO4-p53 interaction, triggering apoptosis in senescent cells while sparing healthy ones. Dosed daily in micrograms - a 10 mg vial in 3 mL gives about 3.33 mg/mL. No human clinical dosing data exists; the published record is entirely preclinical.

Buy FOXO4-DRI

Research Equipment

SyringesU-100 insulin · 1 mL · 29–31G

Alcohol wipes70% isopropyl prep pads

Serum base — for topical mixesHyaluronic acid serum for mixing peptides into a serum

Electric cooler caseTSA-approved travel cooler — keeps mixed vials at fridge temperature

Storage caseHard carry case for vials

Paid affiliate links.

Common Questions — FOXO4-DRI

How much bacteriostatic water do I add to a 10 mg vial of FOXO4-DRI?

Adding 2 mL of bacteriostatic water to a 10 mg vial gives 5 mg/mL. That is the mix every number on this page is worked out from — change the water figure in the calculator and all the draw amounts update.

What dose of FOXO4-DRI is used in research?

Published and reported figures for FOXO4-DRI run from 5 mg, typically every other day ×3. This site lists each figure with the source it came from rather than giving a single recommended number.

How many units on the syringe is a 250 mcg dose of FOXO4-DRI?

At 5 mg/mL, a 250 mcg dose is 5 units on a 1 mL U-100 insulin syringe. One vial at that mix gives about 40 doses.

How strong is the evidence behind these FOXO4-DRI doses?

FOXO4-DRI is graded preclinical. Laboratory and animal data only. No human dosing trials have been published. We grade every compound on this site so you can weigh the numbers accordingly — the full method is on our editorial policy page.

Where These Numbers Come From

Preclinical — Preclinical and in-vitro data only — no human dosing trials

Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging Baar MP, et al. Cell, 2017

The originating senolytic study; the sole substantive reference for this compound.

Find on PubMed ↗

Newest Studies — —

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Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

FOXO4-DRI Dosage & Reconstitution