Research Use Only · Dosing data compiled from published literature · Not for human or veterinary use

Epitalon Dosage & Reconstitution

Epithalon, Ala-Glu-Asp-Gly (AEDG). Work out exactly what to draw for your own mix, see the doses used in research, and follow a week-by-week plan. Evidence tier: limited.

1Set Up Your Mix

16.667 mg/mL · 16667 mcg/mL

Your Answer — Epitalon

50 mg in 3 mL
60Draw To This Line
0.6That's This Many mL
5Doses In The Vial
0102030405060708090100 U-100 syringe · 1 mL · 100 units draw to 60
50 mg ÷ 3 mL = 16.667 mg/mL  →  10 mg ÷ 16.667 mg/mL = 0.6 mL  →  × 100 = 60 units
Looks good. Draw to 60 units on a 1 mL syringe. That is an easy amount to measure, and this vial gives you 5 doses.
When to dose
Time of dayAt night, roughly 30–60 minutes before bed.
FoodWith or without food.

The pineal bioregulators are studied in the context of melatonin and circadian signalling, and the protocols they come from specify evening dosing.

2Week-By-Week Plan — Epitalon

Three protocols — pick one, do not stack them
WhenDoseHow OftenHow Many mLDraw ToNumber Of DosesPeptide Used
Ukrainian protocol · first cycle
one injection on days 1, 5, 9, 13 and 17 — five in total
10 mg twice weekly 0.6 mL 60 u 6 60 mg
Standard protocol
once a day for 10 consecutive days
5 mg daily 0.3 mL 30 u 14 70 mg
Maximum protocol
once a day for 10 consecutive days
10 mg daily 0.6 mL 60 u 14 140 mg
Time until the top dose
one cycle, repeated 2–3× a year
Peptide used getting there
0 mg
Vials you'll need
— × 50 mg
Once you're at the top dose
140 mg / 4 wk · 2.8 vials
Where this plan came from
A published protocol
Where this came from: researchdosing.com. These are alternatives, not steps to work through. The Ukrainian protocol is the one suggested for a first cycle. Dose at night, ideally 30–60 minutes before bed. Intramuscular is preferred over subcutaneous. Repeat a cycle two to three times a year rather than running it continuously. Figures shown are for a 50 mg vial in 3 mL.

3Common Doses — Epitalon

worked out for your mix
LevelDoseHow OftenHow Many mLDraw ToDoses In Vial
Ukrainian protocol — first cycle 10 mg days 1, 5, 9, 13 and 17 0.6 mL 60 u 5 doses
Standard protocol 5 mg once daily for 10 days 0.3 mL 30 u 10 doses
Maximum protocol 10 mg once daily for 10 days 0.6 mL 60 u 5 doses
Please read this. These numbers come from published research. They are here as reference, not as instructions. A lot of them come from lab studies rather than studies in people, and some of these peptides have never been given to a person at all.

About Epitalon

Longevity & Bioregulator
Also known as
Epithalon, Ala-Glu-Asp-Gly (AEDG)
Class
Longevity & Bioregulator
Route
Subcutaneous
Half-life
Very short
Evidence tier
Limited

A synthetic tetrapeptide from the Khavinson bioregulator programme, associated with telomerase activation and pineal regulation claims. The supporting literature is overwhelmingly from a single Russian research group, largely in journals with limited international peer review, and has not been independently replicated at scale.

Buy Epitalon

Common Questions — Epitalon

How much bacteriostatic water do I add to a 50 mg vial of Epitalon?

Adding 3 mL of bacteriostatic water to a 50 mg vial gives 16.7 mg/mL. That is the mix every number on this page is worked out from — change the water figure in the calculator and all the draw amounts update.

What dose of Epitalon is used in research?

Published and reported figures for Epitalon are 5 mg or 10 mg per injection, run as a short cycle two to three times a year. This site lists each figure with the source it came from rather than giving a single recommended number.

How many units on the syringe is a 10 mg dose of Epitalon?

At 16.7 mg/mL, a 10 mg dose is 60 units on a 1 mL U-100 insulin syringe. One vial at that mix gives about 5 doses.

How strong is the evidence behind these Epitalon doses?

Epitalon is graded limited. The figures are sparse — a single programme or community-reported numbers. We grade every compound on this site so you can weigh the numbers accordingly — the full method is on our editorial policy page.

Where These Numbers Come From

Limited — Sparse, single-programme, or community-reported figures
Peptides and ageing — the Khavinson bioregulator programme Khavinson VK. Neuroendocrinology Letters, 2002 and subsequent
Primary programme reference. Read critically: single-group, limited independent replication.
Find on PubMed ↗
Effect of epitalon on telomerase activity and telomere length in human somatic cells Khavinson VK, et al. Bulletin of Experimental Biology and Medicine, 2003
The specific telomerase claim, in vitro.
Find on PubMed ↗
Pineal peptide preparation Epithalamin — long-term survival data Anisimov VN, et al. Mechanisms of Ageing and Development, 2003
The lifespan data underlying the anti-ageing framing.
Find on PubMed ↗

Newest Studies —

Not reviewed by us. This list is pulled straight from Europe PMC as papers are published. Nobody has checked whether these are any good, or whether they change anything above. The dose numbers on this page only ever change after a person reviews the evidence.

Other longevity & bioregulator peptides

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Bioregulator tripeptide associated with bronchopulmonary tissue claims.…

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